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<i>Glarea lozoyensis</i> Bills et Pelaez

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編號:B167657

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產品名稱	Glarea lozoyensis Bills et Pelaez
商品貨號	B167657
Deposited As	Zalerion arboricola Buczacki
Strain Designations	MF5533
Application	Produces L 688786 pneumocandin B0 Produces antibiotic cyclic lipopeptide and derivatives
Biosafety Level	1 Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
Product Format	frozen
Storage Conditions	Frozen: -80°C or colder Freeze-Dried: 2°C to 8°C Live Culture: See Propagation Section
Type Strain	no
Disclosure	This material is cited in a US or other Patent and may not be used to infringe the claims. Depending on the wishes of the Depositor, ATCC may be required to inform the Patent Depositor of the party to which the material was furnished. This material may not have been produced or characterized by ATCC.
Preceptrol®	no
Genome Sequenced Strain	Yes
Comments	Genome sequencing strain (Institute of Pharmaceutical Sciences, Germany)
Morphology	After one month on Blakeslee’s MEA at 25°C, colonies slow-growing, restricted, submerged to flat, brown. Hyphae hyaline to pigmented, guttulate. Chlamydospores terminal or intercalary, in chains. No sporulation observed.
Medium	ATCC^® Medium 325: Malt extract agar (Blakeslee's formula) ATCC^® Medium 336: Potato dextrose agar (PDA) ATCC^® Medium 28: Emmons' modification of Sabouraud's agar
Growth Conditions	Temperature: 24°C to 26°C Atmosphere: Typical aerobic
Sequenced Data	18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, 5.8S ribosomal RNA gene, and internal transcribed spacer 2, complete sequence; and 28S ribosomal RNA gene, partial sequence GGTTTCCGTAGGTGAACCTGCGGAAGGATCATTACAGTGTTCCCTGCCCTCGCGGGTAGAAACGCCCACCCTTGTGTAATATATCATGTTGCTTTGGCAGGCCGCCCTCGGGCACCGGCTCCGGCCGGGTCGCGCCTGCCAGAGGACCCCAAACTCTGAATGTTAGTGTCGTCTGAGTACTATATAATAGTTAAAACTTTCAACAACGGATCTCTTGGTTCTGGCATCGATGAAGAACGCAGCGAAATGCGATAAGTAATGTGAATTGCAGAATTCAGTGAATCATCGAATCTTTGAACGCACATTGCGCCCCGTGGTATTCCGCGGGGCATGCCTGTTCGAGCGTCATTTAAACCAATCCAGCTTGCTGGGTCTTGGGCTCTCGCCTCCGGGCGGGCCTTAAAATCAGTGGCGGCGCCACCCGGCTCTAAGCGTAGTAATACTCCTCGCTACAGGGCTCCGGGTGGAGGCTGGCCAACAACCCCCAATTTTATCAGGTTGACCTCGGATCAGGTAGGGATACCCGCTGAACTTAAGCATATCAATAA D1D2 region of the 28S ribosomal RNA gene ATATCAATAAGCGGAGGAAAAGAAACCAACAGGGATTACCTCAGTAACGGCGAGTGAAGCGGTAACAGCTCAAATTTGAAATCTGGCTCTTTTAGGGTCCGAGTTGTAATTTGTAGAAGATGCTTCGGGTGTAGCTCCGGTCTAAGTTCCTTGGAACAGGACGTCATAGAGGGTGAGAATCCCGTATGTGACTGGTGGCTTTCGCCCATGTGAAGCTCTTTCGACGAGTCGAGTTGTTTGGGAATGCAGCTCTAAATGGGTGGTAAATTTCATCTAAAGCTAAATATTGGCCAGAGACCGATAGCGCACAAGTAGAGTGATCGAAAGATGAAAAGCACTTTGGAAAGAGAGTTAAACAGTACGTGAAATTGTTGAAAGGGAAGCGCTTGCAACCAGACTTGCACCCCGTCGATCATCCCCCGTTCTCGGAGGTGCACTCGGCGGGGTTCAGGCCAGCATCGGTTTCGGTGGTGGGATAAAGGCCTTGGGAACGTAGCTCCTCTCGGGGAGTGTTATAGCCCTCGGTGCAATGCCGCCTACCGGGACCGAGGACCGCGCTTCGGCTAGGATGCTGGCGTAATGGTTGTAAGCGAC
Name of Depositor	Merck & Co., Inc.
U.S. Patent Number	5,306,708
Special Collection	NCRR Contract
Isolation	Mutant derived from ATCC 20957
Cross References	Nucleotide (GenBank) : AGUE00000000 Glarea lozoyensis 74030, whole genome shotgun sequencing project
References	Adefarati AA, et al. Pneumocandins from Zalerion arboricola. V. Glutamic acid- and leucine-derived amino acids in pneumocandin A0 (L-671,329) and distinct origins of the substituted proline residues in pneumocandins A0 and B0. J. Antibiot. 45: 1953-1957, 1992. PubMed: 1362720 Bills GF, et al. Reclassification of a pneumocandin-producing anamorph, Glarea lozoyensis gen. et sp. nov., previously identified as Zalerion arboricola. Mycol. Res. 103: 179-192, 1999. Hammond ML, et al. Lipopeptide derivatives. US Patent 5,369,093 dated Nov 29 1994 Masurekar PS, et al. Pneumocandins from Zalerion arboricola. II. Modification of productspectrum by mutation and medium manipulation. J. Antibiot. 45: 1867-1874, 1992. PubMed: 1490877 Schwartz RE, et al. Antibiotic agent. US Patent 5,306,708 dated Apr 26 1994 Youssar L, et al. Genome sequence of the fungus Glarea lozoyensis: the first genome sequence of a species from the Helotiaceae family. Eukaryot Cell 11: 250, 2012. PubMed: 22302591

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